Vitamin D inhibits lymphangiogenesis through VDR-dependent mechanisms
Identifieur interne : 000025 ( Main/Exploration ); précédent : 000024; suivant : 000026Vitamin D inhibits lymphangiogenesis through VDR-dependent mechanisms
Auteurs : Saleh Yazdani [Pays-Bas] ; Fariba Poosti [Pays-Bas] ; Luis Toro [Pays-Bas, Chili] ; Johannes Wedel [Pays-Bas] ; Rik Mencke [Pays-Bas] ; Katarina Mirkovi [Pays-Bas] ; Martin H. De Borst [Pays-Bas] ; J. Steven Alexander [États-Unis] ; Gerjan Navis [Pays-Bas] ; Harry Van Goor [Pays-Bas] ; Jacob Van Den Born [Pays-Bas] ; Jan-Luuk Hillebrands [Pays-Bas]Source :
- Scientific Reports [ 2045-2322 ] ; 2017.
Abstract
Excessive lymphangiogenesis is associated with cancer progression and renal disease. Attenuation of lymphangiogenesis might represent a novel strategy to target disease progression although clinically approved anti-lymphangiogenic drugs are not available yet. VitaminD(VitD)-deficiency is associated with increased cancer risk and chronic kidney disease. Presently, effects of VitD on lymphangiogenesis are unknown. Given the apparently protective effects of VitD and the deleterious associations of lymphangiogenesis with renal disease, we here tested the hypothesis that VitD has direct anti-lymphangiogenic effects
Url:
DOI: 10.1038/srep44403
PubMed: 28303937
PubMed Central: 5355885
Affiliations:
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Luuk" uniqKey="Hillebrands J" first="Jan-Luuk" last="Hillebrands">Jan-Luuk Hillebrands</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Pathology and Medical Biology, Division of Pathology, University of Groningen, University Medical Center Groningen</institution>, Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28303937</idno><idno type="pmc">5355885</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355885</idno><idno type="RBID">PMC:5355885</idno><idno type="doi">10.1038/srep44403</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000980</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000980</idno><idno type="wicri:Area/Pmc/Curation">000980</idno><idno 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Groningen</institution>, Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Poosti, Fariba" sort="Poosti, Fariba" uniqKey="Poosti F" first="Fariba" last="Poosti">Fariba Poosti</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Pathology and Medical Biology, Division of Pathology, University of Groningen, University Medical Center Groningen</institution>, Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Toro, Luis" sort="Toro, Luis" uniqKey="Toro L" first="Luis" last="Toro">Luis Toro</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Pathology and Medical Biology, Division of Pathology, University of Groningen, University Medical Center Groningen</institution>, Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Seccion de Nefrologia, Departamento de Medicina, Hospital Clinico Universidad de Chile</institution>, Santiago,<country>Chile</country></nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Centro de Investigacion Clinica Avanzada, Hospital Clinico Universidad de Chile</institution>, Santiago,<country>Chile</country></nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wedel, Johannes" sort="Wedel, Johannes" uniqKey="Wedel J" first="Johannes" last="Wedel">Johannes Wedel</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Pathology and Medical Biology, Division of Pathology, University of Groningen, University Medical Center Groningen</institution>, Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mencke, Rik" sort="Mencke, Rik" uniqKey="Mencke R" first="Rik" last="Mencke">Rik Mencke</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Pathology and Medical Biology, Division of Pathology, University of Groningen, University Medical Center Groningen</institution>, Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mirkovi, Katarina" sort="Mirkovi, Katarina" uniqKey="Mirkovi K" first="Katarina" last="Mirkovi">Katarina Mirkovi</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen</institution>, Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="De Borst, Martin H" sort="De Borst, Martin H" uniqKey="De Borst M" first="Martin H." last="De Borst">Martin H. De Borst</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen</institution>, Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Alexander, J Steven" sort="Alexander, J Steven" uniqKey="Alexander J" first="J. Steven" last="Alexander">J. Steven Alexander</name><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center-Shreveport</institution>, Louisiana,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Navis, Gerjan" sort="Navis, Gerjan" uniqKey="Navis G" first="Gerjan" last="Navis">Gerjan Navis</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen</institution>, Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Goor, Harry" sort="Van Goor, Harry" uniqKey="Van Goor H" first="Harry" last="Van Goor">Harry Van Goor</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Pathology and Medical Biology, Division of Pathology, University of Groningen, University Medical Center Groningen</institution>, Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Den Born, Jacob" sort="Van Den Born, Jacob" uniqKey="Van Den Born J" first="Jacob" last="Van Den Born">Jacob Van Den Born</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen</institution>, Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hillebrands, Jan Luuk" sort="Hillebrands, Jan Luuk" uniqKey="Hillebrands J" first="Jan-Luuk" last="Hillebrands">Jan-Luuk Hillebrands</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Pathology and Medical Biology, Division of Pathology, University of Groningen, University Medical Center Groningen</institution>, Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Excessive lymphangiogenesis is associated with cancer progression and renal disease. Attenuation of lymphangiogenesis might represent a novel strategy to target disease progression although clinically approved anti-lymphangiogenic drugs are not available yet. VitaminD(VitD)-deficiency is associated with increased cancer risk and chronic kidney disease. Presently, effects of VitD on lymphangiogenesis are unknown. Given the apparently protective effects of VitD and the deleterious associations of lymphangiogenesis with renal disease, we here tested the hypothesis that VitD has direct anti-lymphangiogenic effects <italic>in vitro</italic> and is able to attenuate lymphangiogenesis <italic>in vivo. In vitro</italic> cultured mouse lymphatic endothelial cells (LECs) expressed VitD Receptor (VDR), both on mRNA and protein levels. Active VitD (calcitriol) blocked LEC tube formation, reduced LEC proliferation, and induced LEC apoptosis. siRNA-mediated VDR knock-down reversed the inhibitory effect of calcitriol on LEC tube formation, demonstrating how such inhibition is VDR-dependent. <italic>In vivo,</italic> proteinuric rats were treated with vehicle or paricalcitol for 6 consecutive weeks. Compared with vehicle-treated proteinuric rats, paricalcitol showed markedly reduced renal lymphangiogenesis. In conclusion, our data show that VitD is anti-lymphangiogenic through VDR-dependent anti-proliferative and pro-apoptotic mechanisms. Our findings highlight an important novel function of VitD demonstrating how it may have therapeutic value in diseases accompanied by pathological lymphangiogenesis.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name></author><author><name sortKey="Oliver, G" uniqKey="Oliver G">G. Oliver</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K. Alitalo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kerjaschki, D" uniqKey="Kerjaschki D">D. Kerjaschki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yazdani, S" uniqKey="Yazdani S">S. Yazdani</name></author><author><name sortKey="Navis, G" uniqKey="Navis G">G. Navis</name></author><author><name sortKey="Hillebrands, J L" uniqKey="Hillebrands J">J. L. Hillebrands</name></author><author><name sortKey="Van Goor, H" uniqKey="Van Goor H">H. van Goor</name></author><author><name sortKey="Van Den Born, J" uniqKey="Van Den Born J">J. van den Born</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baker, A" uniqKey="Baker A">A. Baker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dietrich, T" uniqKey="Dietrich T">T. Dietrich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yan, H" uniqKey="Yan H">H. Yan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tang, X L" uniqKey="Tang X">X. L. Tang</name></author><author><name sortKey="Sun, J F" uniqKey="Sun J">J. F. Sun</name></author><author><name sortKey="Wang, X Y" uniqKey="Wang X">X. Y. Wang</name></author><author><name sortKey="Du, L L" uniqKey="Du L">L. L. Du</name></author><author><name sortKey="Liu, P" uniqKey="Liu P">P. Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nykanen, A I" uniqKey="Nykanen A">A. I. Nykanen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yin, N" uniqKey="Yin N">N. Yin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Halin, C" uniqKey="Halin C">C. Halin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huggenberger, R" uniqKey="Huggenberger R">R. Huggenberger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dieterich, L C" uniqKey="Dieterich L">L. C. Dieterich</name></author><author><name sortKey="Seidel, C D" uniqKey="Seidel C">C. D. Seidel</name></author><author><name sortKey="Detmar, M" uniqKey="Detmar M">M. Detmar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="El Chemaly, S" uniqKey="El Chemaly S">S. El-Chemaly</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meinecke, A K" uniqKey="Meinecke A">A. K. Meinecke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, S" uniqKey="Li S">S. Li</name></author><author><name sortKey="Li, Q" uniqKey="Li Q">Q. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hos, D" uniqKey="Hos D">D. Hos</name></author><author><name sortKey="Schlereth, S L" uniqKey="Schlereth S">S. L. Schlereth</name></author><author><name sortKey="Bock, F" uniqKey="Bock F">F. Bock</name></author><author><name sortKey="Heindl, L M" uniqKey="Heindl L">L. M. Heindl</name></author><author><name sortKey="Cursiefen, C" uniqKey="Cursiefen C">C. Cursiefen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Verstuyf, A" uniqKey="Verstuyf A">A. Verstuyf</name></author><author><name sortKey="Carmeliet, G" uniqKey="Carmeliet G">G. Carmeliet</name></author><author><name sortKey="Bouillon, R" uniqKey="Bouillon R">R. Bouillon</name></author><author><name sortKey="Mathieu, C" uniqKey="Mathieu C">C. Mathieu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Christakos, S" uniqKey="Christakos S">S. Christakos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mocellin, S" uniqKey="Mocellin S">S. Mocellin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Norman, P E" uniqKey="Norman P">P. E. Norman</name></author><author><name sortKey="Powell, J T" uniqKey="Powell J">J. T. Powell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Merke, J" uniqKey="Merke J">J. Merke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Al Mheid, I" uniqKey="Al Mheid I">I. Al Mheid</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oades, G M" uniqKey="Oades G">G. M. Oades</name></author><author><name sortKey="Dredge, K" uniqKey="Dredge K">K. Dredge</name></author><author><name sortKey="Kirby, R S" uniqKey="Kirby R">R. S. Kirby</name></author><author><name sortKey="Colston, K W" uniqKey="Colston K">K. W. Colston</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Valrance, M E" uniqKey="Valrance M">M. E. Valrance</name></author><author><name sortKey="Brunet, A H" uniqKey="Brunet A">A. H. Brunet</name></author><author><name sortKey="Welsh, J" uniqKey="Welsh J">J. Welsh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pittarella, P" uniqKey="Pittarella P">P. Pittarella</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mantell, D J" uniqKey="Mantell D">D. J. Mantell</name></author><author><name sortKey="Owens, P E" uniqKey="Owens P">P. E. Owens</name></author><author><name sortKey="Bundred, N J" uniqKey="Bundred N">N. J. Bundred</name></author><author><name sortKey="Mawer, E B" uniqKey="Mawer E">E. B. Mawer</name></author><author><name sortKey="Canfield, A E" uniqKey="Canfield A">A. E. Canfield</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zoccali, C" uniqKey="Zoccali C">C. Zoccali</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ponticelli, C" uniqKey="Ponticelli C">C. Ponticelli</name></author><author><name sortKey="Sala, G" uniqKey="Sala G">G. Sala</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Borst, M H" uniqKey="De Borst M">M. H. de Borst</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mirkovic, K" uniqKey="Mirkovic K">K. Mirkovic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Doorenbos, C R" uniqKey="Doorenbos C">C. R. Doorenbos</name></author><author><name sortKey="Van Den Born, J" uniqKey="Van Den Born J">J. van den Born</name></author><author><name sortKey="Navis, G" uniqKey="Navis G">G. Navis</name></author><author><name sortKey="De Borst, M H" uniqKey="De Borst M">M. H. de Borst</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mirkovic, K" uniqKey="Mirkovic K">K. Mirkovic</name></author><author><name sortKey="Van Den Born, J" uniqKey="Van Den Born J">J. van den Born</name></author><author><name sortKey="Navis, G" uniqKey="Navis G">G. Navis</name></author><author><name sortKey="De Borst, M H" uniqKey="De Borst M">M. H. de Borst</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name></author><author><name sortKey="Borchert, M L" uniqKey="Borchert M">M. L. Borchert</name></author><author><name sortKey="Deluca, H F" uniqKey="Deluca H">H. F. Deluca</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yazdani, S" uniqKey="Yazdani S">S. Yazdani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Szuba, A" uniqKey="Szuba A">A. Szuba</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cheung, L" uniqKey="Cheung L">L. Cheung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, H" uniqKey="Kim H">H. Kim</name></author><author><name sortKey="Kataru, R P" uniqKey="Kataru R">R. P. Kataru</name></author><author><name sortKey="Koh, G Y" uniqKey="Koh G">G. Y. Koh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cui, Y" uniqKey="Cui Y">Y. Cui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dieterich, L C" uniqKey="Dieterich L">L. C. Dieterich</name></author><author><name sortKey="Detmar, M" uniqKey="Detmar M">M. Detmar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chiang, K C" uniqKey="Chiang K">K. C. Chiang</name></author><author><name sortKey="Chen, T C" uniqKey="Chen T">T. C. Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lansink, M" uniqKey="Lansink M">M. Lansink</name></author><author><name sortKey="Koolwijk, P" uniqKey="Koolwijk P">P. Koolwijk</name></author><author><name sortKey="Van Hinsbergh, V" uniqKey="Van Hinsbergh V">V. van Hinsbergh</name></author><author><name sortKey="Kooistra, T" uniqKey="Kooistra T">T. Kooistra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, R" uniqKey="Lin R">R. Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yamamoto, T" uniqKey="Yamamoto T">T. Yamamoto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grundmann, M" uniqKey="Grundmann M">M. Grundmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zehnder, D" uniqKey="Zehnder D">D. Zehnder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bikle, D D" uniqKey="Bikle D">D. D. Bikle</name></author><author><name sortKey="Pillai, S" uniqKey="Pillai S">S. Pillai</name></author><author><name sortKey="Gee, E" uniqKey="Gee E">E. Gee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bollag, W B" uniqKey="Bollag W">W. B. Bollag</name></author><author><name sortKey="Ducote, J" uniqKey="Ducote J">J. Ducote</name></author><author><name sortKey="Harmon, C S" uniqKey="Harmon C">C. S. Harmon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Deeb, K K" uniqKey="Deeb K">K. K. Deeb</name></author><author><name sortKey="Trump, D L" uniqKey="Trump D">D. L. Trump</name></author><author><name sortKey="Johnson, C S" uniqKey="Johnson C">C. S. Johnson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, T C" uniqKey="Chen T">T. C. Chen</name></author><author><name sortKey="Holick, M F" uniqKey="Holick M">M. F. Holick</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chiang, K C" uniqKey="Chiang K">K. C. Chiang</name></author><author><name sortKey="Yeh, C N" uniqKey="Yeh C">C. N. Yeh</name></author><author><name sortKey="Chen, M F" uniqKey="Chen M">M. F. Chen</name></author><author><name sortKey="Chen, T C" uniqKey="Chen T">T. C. Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Polek, T C" uniqKey="Polek T">T. C. Polek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bover, J" uniqKey="Bover J">J. Bover</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cozzolino, M" uniqKey="Cozzolino M">M. Cozzolino</name></author><author><name sortKey="B, J" uniqKey="B J">J. B.</name></author><author><name sortKey="Vervloet, M" uniqKey="Vervloet M">M. Vervloet</name></author><author><name sortKey="Brandenburg, V M" uniqKey="Brandenburg V">V. M. Brandenburg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Slatopolsky, E" uniqKey="Slatopolsky E">E. Slatopolsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arnaoutova, I" uniqKey="Arnaoutova I">I. Arnaoutova</name></author><author><name sortKey="George, J" uniqKey="George J">J. George</name></author><author><name sortKey="Kleinman, H K" uniqKey="Kleinman H">H. K. Kleinman</name></author><author><name sortKey="Benton, G" uniqKey="Benton G">G. Benton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Luo, Y" uniqKey="Luo Y">Y. Luo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kubota, Y" uniqKey="Kubota Y">Y. Kubota</name></author><author><name sortKey="Kleinman, H K" uniqKey="Kleinman H">H. K. Kleinman</name></author><author><name sortKey="Martin, G R" uniqKey="Martin G">G. R. Martin</name></author><author><name sortKey="Lawley, T J" uniqKey="Lawley T">T. J. Lawley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leak, L V" uniqKey="Leak L">L. V. Leak</name></author><author><name sortKey="Jones, M" uniqKey="Jones M">M. Jones</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Chili</li><li>Pays-Bas</li><li>États-Unis</li></country></list><tree><country name="Pays-Bas"><noRegion><name sortKey="Yazdani, Saleh" sort="Yazdani, Saleh" uniqKey="Yazdani S" first="Saleh" last="Yazdani">Saleh Yazdani</name></noRegion><name sortKey="De Borst, Martin H" sort="De Borst, Martin H" uniqKey="De Borst M" first="Martin H." last="De Borst">Martin H. De Borst</name><name sortKey="Hillebrands, Jan Luuk" sort="Hillebrands, Jan Luuk" uniqKey="Hillebrands J" first="Jan-Luuk" last="Hillebrands">Jan-Luuk Hillebrands</name><name sortKey="Mencke, Rik" sort="Mencke, Rik" uniqKey="Mencke R" first="Rik" last="Mencke">Rik Mencke</name><name sortKey="Mirkovi, Katarina" sort="Mirkovi, Katarina" uniqKey="Mirkovi K" first="Katarina" last="Mirkovi">Katarina Mirkovi</name><name sortKey="Navis, Gerjan" sort="Navis, Gerjan" uniqKey="Navis G" first="Gerjan" last="Navis">Gerjan Navis</name><name sortKey="Poosti, Fariba" sort="Poosti, Fariba" uniqKey="Poosti F" first="Fariba" last="Poosti">Fariba Poosti</name><name sortKey="Toro, Luis" sort="Toro, Luis" uniqKey="Toro L" first="Luis" last="Toro">Luis Toro</name><name sortKey="Van Den Born, Jacob" sort="Van Den Born, Jacob" uniqKey="Van Den Born J" first="Jacob" last="Van Den Born">Jacob Van Den Born</name><name sortKey="Van Goor, Harry" sort="Van Goor, Harry" uniqKey="Van Goor H" first="Harry" last="Van Goor">Harry Van Goor</name><name sortKey="Wedel, Johannes" sort="Wedel, Johannes" uniqKey="Wedel J" first="Johannes" last="Wedel">Johannes Wedel</name></country><country name="Chili"><noRegion><name sortKey="Toro, Luis" sort="Toro, Luis" uniqKey="Toro L" first="Luis" last="Toro">Luis Toro</name></noRegion><name sortKey="Toro, Luis" sort="Toro, Luis" uniqKey="Toro L" first="Luis" last="Toro">Luis Toro</name></country><country name="États-Unis"><noRegion><name sortKey="Alexander, J Steven" sort="Alexander, J Steven" uniqKey="Alexander J" first="J. Steven" last="Alexander">J. Steven Alexander</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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